Epigenetics

Infancy and early childhood are highly sensitive periods in human development. DNA methylation (DNAme), an epigenetic tag that is deposited on DNA, has been proposed as one of the mechanisms by which early life experiences can become biologically embedded. This project aims to model DNA methylation variability and the contribution of genetic variation and environmental differences to it.

Presentation at the Vancouver Bioinformatics User Group meeting in September 2023. Sharing the stage with my supervisor Dr. Keegan Korthauer, who talks about the overall research themes in our lab.

R package whose goal is to identify Variable Methylated Regions (VMRs) in microarray DNA methylation data. Additionally, using Genotype (G) and Environmental (E) data, it can identify which G, E, G+E or GxE model better explains this variability.s

Identification of potential epigenetic key players during COVID-19 infection using integrative analyses of gene co-expression networks and de-novo pathway enrichment.

Undergraduate thesis. Trancriptomic analysis to study the effect of DAXX, a H3.3 histone variant chaperone, in human cell lines from lung, colon and glioblastoma. DAXX was found to be associated with mainly tissue-specific genes. Shared disregulated genes were found to be associated with cancer.