Local Ancestry

Progranulin genetic variant rs5848 displays ancestry-specific associations with Alzheimer's disease

Characterization of the GRN cis-regulatory region and ancestry-specific analyses of the Alzheimer’s Disease Sequencing Project reveal that the common progranulin variant rs5848 is associated with Alzheimer’s disease only in East Asian ancestry.

Benjamin E. Life, Erick I. Navarro-Delgado, Oriol Fornes, Jan M. Friedman, Wyeth W. Wasserman, Keegan Korthauer, Blair R. Leavitt